Plasma levels of soluble tumor necrosis factor receptors are associated with cognitive performance in Parkinson's disease.
Identifieur interne : 000475 ( Main/Exploration ); précédent : 000474; suivant : 000476Plasma levels of soluble tumor necrosis factor receptors are associated with cognitive performance in Parkinson's disease.
Auteurs : Natália Pessoa Rocha [Brésil] ; Antônio Lúcio Teixeira ; Paula Luciana Scalzo ; Izabela Guimarães Barbosa ; Mariana Soares De Sousa ; Isabela Boechat Morato ; Erica Leandro Marciano Vieira ; Paulo Pereira Christo ; András Palotás ; Helton José ReisSource :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2014.
English descriptors
- KwdEn :
- Aged, Biological Markers (blood), Cognition (physiology), Cognition Disorders (blood), Cognition Disorders (complications), Cognition Disorders (diagnosis), Executive Function (physiology), Female, Humans, Male, Middle Aged, Neuropsychological Tests, Parkinson Disease (blood), Parkinson Disease (complications), Parkinson Disease (psychology), Receptors, Tumor Necrosis Factor (blood).
- MESH :
- chemical , blood : Biological Markers, Receptors, Tumor Necrosis Factor.
- blood : Cognition Disorders, Parkinson Disease.
- complications : Cognition Disorders, Parkinson Disease.
- diagnosis : Cognition Disorders.
- physiology : Cognition, Executive Function.
- psychology : Parkinson Disease.
- Aged, Female, Humans, Male, Middle Aged, Neuropsychological Tests.
Abstract
Inflammatory mechanisms have been implicated in a series of neuropsychiatric conditions, including behavioral disturbances, cognitive dysfunction, and affective disorders. Accumulating evidence also strongly suggests their involvement in the pathophysiology of Parkinson's disease (PD). This study aimed to evaluate plasma levels of inflammatory biomarkers, and their association with cognitive performance and other non-motor symptoms of PD. PD patients and control individuals were subjected to various psychometric tests, including the Mini-Mental State Examination (MMSE), Frontal Assessment Battery (FAB), and Beck's Depression Inventory (BDI). Biomarker plasma levels were measured by enzyme-linked immunosorbent assay (ELISA). PD patients exhibited worse performance on MMSE and the programming task of FAB, and presented higher soluble tumor necrosis factor receptor (sTNFR) plasma levels than control individuals. Among PD patients, increased sTNFR1 and sTNFR2 concentrations were associated with poorer cognitive test scores. After multiple linear regression, sTNFR1 and education remained a significant predictor for FAB scores. Our data suggest that PD is associated with a proinflammatory profile, and sTNFRs are putative biomarkers of cognitive performance, with elevated sTNFR1 levels predicting poorer executive functioning in PD patients.
DOI: 10.1002/mds.25752
PubMed: 24301904
Affiliations:
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Le document en format XML
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Laboratório de Neurofarmacologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Laboratório Interdisciplinar de Investigação Médica, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil; Laboratório de Neurofarmacologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais</wicri:regionArea><placeName><region type="state">Minas Gerais</region><settlement type="city">Belo Horizonte</settlement></placeName><orgName type="university">Université fédérale du Minas Gerais</orgName></affiliation></author><author><name sortKey="Teixeira, Antonio Lucio" sort="Teixeira, Antonio Lucio" uniqKey="Teixeira A" first="Antônio Lúcio" last="Teixeira">Antônio Lúcio Teixeira</name></author><author><name sortKey="Scalzo, Paula Luciana" sort="Scalzo, Paula Luciana" uniqKey="Scalzo P" first="Paula Luciana" last="Scalzo">Paula Luciana Scalzo</name></author><author><name sortKey="Barbosa, Izabela Guimaraes" sort="Barbosa, Izabela Guimaraes" uniqKey="Barbosa I" first="Izabela Guimarães" last="Barbosa">Izabela Guimarães Barbosa</name></author><author><name sortKey="De Sousa, Mariana Soares" sort="De Sousa, Mariana Soares" uniqKey="De Sousa M" first="Mariana Soares" last="De Sousa">Mariana Soares De Sousa</name></author><author><name sortKey="Morato, Isabela Boechat" sort="Morato, Isabela Boechat" uniqKey="Morato I" first="Isabela Boechat" last="Morato">Isabela Boechat Morato</name></author><author><name sortKey="Vieira, Erica Leandro Marciano" sort="Vieira, Erica Leandro Marciano" uniqKey="Vieira E" first="Erica Leandro Marciano" last="Vieira">Erica Leandro Marciano Vieira</name></author><author><name sortKey="Christo, Paulo Pereira" sort="Christo, Paulo Pereira" uniqKey="Christo P" first="Paulo Pereira" last="Christo">Paulo Pereira Christo</name></author><author><name sortKey="Palotas, Andras" sort="Palotas, Andras" uniqKey="Palotas A" first="András" last="Palotás">András Palotás</name></author><author><name sortKey="Reis, Helton Jose" sort="Reis, Helton Jose" uniqKey="Reis H" first="Helton José" last="Reis">Helton José Reis</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="eISSN">1531-8257</idno><imprint><date when="2014" type="published">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Biological Markers (blood)</term><term>Cognition (physiology)</term><term>Cognition Disorders (blood)</term><term>Cognition Disorders (complications)</term><term>Cognition Disorders (diagnosis)</term><term>Executive Function (physiology)</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Neuropsychological Tests</term><term>Parkinson Disease (blood)</term><term>Parkinson Disease (complications)</term><term>Parkinson Disease (psychology)</term><term>Receptors, Tumor Necrosis Factor (blood)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Biological Markers</term><term>Receptors, Tumor Necrosis Factor</term></keywords><keywords scheme="MESH" qualifier="blood" xml:lang="en"><term>Cognition Disorders</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Cognition Disorders</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Cognition Disorders</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Cognition</term><term>Executive Function</term></keywords><keywords scheme="MESH" qualifier="psychology" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Neuropsychological Tests</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Inflammatory mechanisms have been implicated in a series of neuropsychiatric conditions, including behavioral disturbances, cognitive dysfunction, and affective disorders. Accumulating evidence also strongly suggests their involvement in the pathophysiology of Parkinson's disease (PD). This study aimed to evaluate plasma levels of inflammatory biomarkers, and their association with cognitive performance and other non-motor symptoms of PD. PD patients and control individuals were subjected to various psychometric tests, including the Mini-Mental State Examination (MMSE), Frontal Assessment Battery (FAB), and Beck's Depression Inventory (BDI). Biomarker plasma levels were measured by enzyme-linked immunosorbent assay (ELISA). PD patients exhibited worse performance on MMSE and the programming task of FAB, and presented higher soluble tumor necrosis factor receptor (sTNFR) plasma levels than control individuals. Among PD patients, increased sTNFR1 and sTNFR2 concentrations were associated with poorer cognitive test scores. After multiple linear regression, sTNFR1 and education remained a significant predictor for FAB scores. Our data suggest that PD is associated with a proinflammatory profile, and sTNFRs are putative biomarkers of cognitive performance, with elevated sTNFR1 levels predicting poorer executive functioning in PD patients.</div></front></TEI><affiliations><list><country><li>Brésil</li></country><region><li>Minas Gerais</li></region><settlement><li>Belo Horizonte</li></settlement><orgName><li>Université fédérale du Minas Gerais</li></orgName></list><tree><noCountry><name sortKey="Barbosa, Izabela Guimaraes" sort="Barbosa, Izabela Guimaraes" uniqKey="Barbosa I" first="Izabela Guimarães" last="Barbosa">Izabela Guimarães Barbosa</name><name sortKey="Christo, Paulo Pereira" sort="Christo, Paulo Pereira" uniqKey="Christo P" first="Paulo Pereira" last="Christo">Paulo Pereira Christo</name><name sortKey="De Sousa, Mariana Soares" sort="De Sousa, Mariana Soares" uniqKey="De Sousa M" first="Mariana Soares" last="De Sousa">Mariana Soares De Sousa</name><name sortKey="Morato, Isabela Boechat" sort="Morato, Isabela Boechat" uniqKey="Morato I" first="Isabela Boechat" last="Morato">Isabela Boechat Morato</name><name sortKey="Palotas, Andras" sort="Palotas, Andras" uniqKey="Palotas A" first="András" last="Palotás">András Palotás</name><name sortKey="Reis, Helton Jose" sort="Reis, Helton Jose" uniqKey="Reis H" first="Helton José" last="Reis">Helton José Reis</name><name sortKey="Scalzo, Paula Luciana" sort="Scalzo, Paula Luciana" uniqKey="Scalzo P" first="Paula Luciana" last="Scalzo">Paula Luciana Scalzo</name><name sortKey="Teixeira, Antonio Lucio" sort="Teixeira, Antonio Lucio" uniqKey="Teixeira A" first="Antônio Lúcio" last="Teixeira">Antônio Lúcio Teixeira</name><name sortKey="Vieira, Erica Leandro Marciano" sort="Vieira, Erica Leandro Marciano" uniqKey="Vieira E" first="Erica Leandro Marciano" last="Vieira">Erica Leandro Marciano Vieira</name></noCountry><country name="Brésil"><region name="Minas Gerais"><name sortKey="Rocha, Natalia Pessoa" sort="Rocha, Natalia Pessoa" uniqKey="Rocha N" first="Natália Pessoa" last="Rocha">Natália Pessoa Rocha</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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